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The Observational Medical Outcomes Partnership (OMOP) held its first annual Symposium on November 12, 2009, in Bethesda, Maryland. In the following segment, Christian Reich, MD, PhD and Alex Chelminsky present the technical requirements for the project with a detailed look into the process of building the OMOP Research Lab. In addition, Shaun Grannis, MD, PhD offers the perspective of a Distributed Data Partner.