This tutorial runs for 18 minutes (size 25 MB) and shows how to do a parameter estimation in Copasi4B24. As in the last tutorial about Copasi we do not create a model from scratch, but import the simple model we developed in our tutorial about CellDesigner. Then we explain the dialog box to start the parameter estimation in Copasi and what the input file with the experimental data has to look like. Using the output assistent we create a plot and a report file of the fitting process. After the fit we have a quick look at the contents of the generated report file. Next we explain how to transfer the fitted parameter values into the model and finally we do a time course run using the fitted values. For this we also explain how to manually setup a plot window for the simulation results.
This video tutorial has been created as supportive material for our book "Systems Biology, A Textbook", ISBN 978-3-527-31874-2 and is also available from .hu-berlin.de/biologie/theorybp/video_tutorials.php
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