Supercomputers at the Oak Ridge Leadership Computing Facility illuminate the workings of the molecular machinery that opens and loads sliding clamps onto DNA. Sliding clamps play vital roles in both DNA replication and repair. Here the clamp loader (with its subunits shown in blue, green, yellow, orange, and red) is depicted in complex with a ring-open sliding clamp (shown in gray) and counterions (spheres).
Image courtesy Ivaylo Ivanov and Mike Matheson
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