Premiere Pro
NTSC / H.264
Frame Rate: 23.976 fps
Bitrate: Variable (target: 5 / Maximum: 8)
Profile: Main
Keyframe: 30

I tried a variety of encoding settings (variable, fixed, various keyframes, H.264 vs. WMV, etc) and this seemed to produce the best result once uploaded to Vimeo.

Take it for what it's worth, and let me know if you've found better.

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