Purdue University Professor Arun Ghosh talks to high school chemistry students about his research in designing enzyme inhibitors for treatment of Alzheimer’s Disease and AIDS.
Dr. Ghosh received the 2010 IUPAC-Richter Prize award in recognition of his outstanding use of structure-based design of HIV-1 protease inhibitors using his novel concept of “backbone binding” to withstand drug resistance. This work produced the novel drug darunavir which was approved by the FDA in 2006 as the first treatment for multidrug resistant HIV. He has also pioneered structure- based design of β-secretase inhibitors for treatment of Alzheimer’s disease. One such compound has now entered into advanced clinical trials.
The IUPAC-Richter Prize has been established by a generous gift from the Chemical Works of Gedeon Richter, Ltd. (Budapest, Hungary) to acknowledge the key role that medicinal chemistry plays in improving human health.
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