Texas Heart follows world-renowned heart surgeons O.H. "Bud" Fraizer and Billy Cohn as they design, implement and perfect a "continuous flow" total artificial heart.

Within the operating rooms of the fabled Texas Heart Institute, these doctors reveal their fascinating field, an industry propelled forward by the hopes of man's triumph over nature, but plagued by realities of history: humanity's questionable motives for technological advancement.

As Frazier, a Vietnam Vet, and Cohn, a Sci-Fi buff, work with their pioneering mentors, Michael DeBakey and Denton Cooley, the famous feuding heart surgeons who started the field, their lives become intertwined with the larger forces pushing mankind into a post-human future.