John Quackenbush (hvrd.me/quakenbush) gives an entertaining and thought-provoking look at developments in the analysis & visualization of high-throughput mRNA data-sets, especially heat-maps. He discusses trends towards centralized repositories, web-based visualization, and highlights the need to better address variance in gene expression, and to better integrate pathways and clinical data. This talk was presented at VIZBI 2011, an international conference series on visualizing biological data (vizbi.org) funded by NIH & EMBO. This video was filmed and distributed with permission under a creative common license. Slides from the talk are at bit.ly/okXOAM