Overcoming Antibacterial Biological Approaches
Deborah Hung, Broad Institute of MIT and Harvard
Given the increasing rates of antibiotic resistance in the majority or clinically relevant infections and the decline in development of antibiotics with new mechanisms to overcome this resistance, it is paramount that renewed efforts are committed to finding new therapeutics to combat these drug-resistant pathogens.
Part of these efforts should include a reimagination of possible strategies to combat pathogens that fall outside of the current model. Such strategies include disruption of the complex interaction between the pathogen and the host through inhibition of pathogen virulence or modulation of host mechanisms that ultimately result in host survival or minimal disease. We are exploring such new paradigms and the feasibility of such approaches as part of a larger program to understand and combat antibiotic resistance.
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