Roadmap from BioNanotechnology to Nanomedicine
Jianzhong (Jeff) Xi, Ph. D.
Biomedical Engineering Department, College of Engineering, Peking University
In this talk, I will first give a mini-review of the recent achievements in bionanotechnology and nanomedicine, which is followed by the introduction of the current research interests in my laboratory.
The marriage of nanotechnology and advanced biological science has promoted the considerable progress of life science and other fields. Here several recent research works will be highlighted and illustrated to show the promise as well as risks each new created technology might bring about. For example, quantum dots have been extensively utilized to replace the conventional Green Fluorescent Protein and fluorescent dyes for the purpose of cancer diagnose due to their excellent stabilities or optical properties. However, the potential risks of this kind of nano-size particles have to be fully investigated before the implantation of them in clinical application in the future. What is more important, I will emphasize the novelty of each example and its potential application in this talk.
In the second part, I will introduce our laboratory research interests. The fabrication of self-assembled muscle-powered microdevices will be fully described and the challenges will be analyzed to explain what we learned during the effort to fulfill this work. Finally, I will spend some time to show our recent achievements in the second research direction, including the function study of miRNA and the isolation and the detection of miRNA, etc.
Background review papers:
1) Kinosita, et al .Nature 2001, vol 410, 898
2) Mirkin et al. Science 2003 301 1884
3) Soong, et al Science 2000, 290, 1555
4) Luo, et al. Nature Materials 2005 Feb. 6
5) Itho, et al, Nature, 427, 465-468
6) Sengupta, S Nature Vol 436 2005
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