A supplemental video from the 2013 review by Guy Major, Matthew E. Larkum, and Jackie Schiller, "Active Properties of Neocortical Pyramidal Neuron Dendrites," from the Annual Review of Neuroscience: annualreviews.org/doi/abs/10.1146/annurev-neuro-062111-150343?utm_source=vimeo&utm_medium=ne.36.schiller&utm_campaign=suppvideo

The supplemental movies show time evolution of I-V curves and membrane potential (Vm) of models, following a brief pulse of glutamate, with AMPAR conductances yielding just subthreshold and just-suprathreshold responses. Pale orange line in top panel and X in bottom right panel indicate threshold when bistable state exists.

In Supplemental Videos 1 and 2, the highest gmax NMDA = 5 × leak. Video 1: gmax AMPA = 2.1 × leak (subthreshold). Video 2: gmax AMPA = 2.2 × leak (suprathreshold). Would see small spike ‘riding on’ big subthreshold response (if superimposed).

Loading more stuff…

Hmm…it looks like things are taking a while to load. Try again?

Loading videos…