Osy is a game being produced as part an NIH/SEPA project at the University of Georgia. This five-year partnership project among scientists and science educators at the University of Georgia, Augusta State University, science teachers in high schools, and the Biological Science Curriculum Study organization is a component of our long-term goal of enticing high school students to consider careers in science. The objectives of this project are to create and rigorously evaluate curricular materials that utilize highly interactive 3-D models and animations of physiological processes as a means for high school students to conduct inquiries into the life-threatening effects of diseases such as diabetes. The inquiry-based learning activities created in this project will cover 7 key biological processes: diffusion, osmosis, filtration, active transport, passive transport, blood pressure, and glucose homeostasis.