Hi everyone. Here is my test results to creation is large scale smoke. Simulation 7 hours, render 10 hours , size 20 GB, time 200 frames. i7-3770 3.4GHz 16 GB ram (for simulation). Video contains the settings that i used for the simulation, i hope they will be useful to you.
Pflow settings: s020.radikal.ru/i718/1311/39/b7182641ca98.jpg
$.Systemscale=0.3

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