Keynote Title: Cells as Bits - Biomedical Diagnostics Inspired by Data Communication Techniques

Keynote Lecturer: Dr. Bahram Jalali

Keynote Chair: Dr. Elvira Fortunato
Presented on: 08-01-2014, Lisbon, Portugal

Abstract: Telecommunication systems routinely generate, capture and analyze data at rates exceeding billions of bits per second. Interestingly, the scale of the problem is similar to that of blood analysis. With approximately 1 billion cells per milliliter of blood, detection of a few abnormal cells in a blood sample translates into a “cell error rate” of 10-12, a value strangely similar to the bit error rate in telecommunication systems.
Motivated by WDM and time-stretch dispersive Fourier transform technologies, a new type of bright-field imaging known as STEAM has demonstrated imaging of cells with record shutter speed and throughput leading to detection of rare breast cancer cells in blood with one-in-a-million sensitivity. A second technique called FIRE is a new approach to fluorescent imaging that is based on wireless communication techniques. FIRE has achieved real-time pixel readout rates one order of magnitude faster than the current gold standard in high-speed fluorescence imaging.
Finally, a new physics-based signal transformation will be introduced and demonstrated. The Anamorphic Stretch Transform enables a digitizer to capture signals that would otherwise be beyond its bandwidth and at the same time, it compresses the digital data volume. This method is inspired by operation of Fovea centralis in the human eye and by anamorphic transformation in visual arts. The Anamorphic Stretch Transform makes it possible to (i) capture high-throughput random signals in real-time and (ii) to alleviate the storage and transmission bottlenecks associated with the resulting “big data”.

Presented at the following Conference: PHOTOPTICS, International Conference on Photonics, Optics and laser Technology

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