Medical Science

Translational Regenerative Medicine
Jennifer Elisseeff, John Hopkins University

Regenerative medicine is a field that aims to rebuild and repair damaged tissues and organs in the body. Human development provides a paradigm and clues that can be harnessed for designing strategies to engineer tissues. During the amazing process of development a single cell multiplies, cell migrate and organize, and ultimately a complex organism is created. The basic building blocks of tissues and organs in our body are cells and the extracellular matrix. Just as the Nature versus Nurture debate plays a role in people’s lives from a sociological perspective, the genetic identity of cells (nature) and local extracellular matrix environment (nurture) present in tissues is critical in development and can be applied to directing tissue repair. The cells in a tissue are constantly interacting with and modulating their local environment while just as importantly the extracellular matrix stores and provides architectural, historical and current environmental information. The basic building blocks of our bodies and the consideration of nature versus nurture is the foundation of biomaterials design in tissue engineering. Biomaterials can be engineered, through physical, chemical and biological means, to provide a temporary scaffold where cells can be directed or coaxed into performing the task of building new tissue and directing repair. Basic research is then required to understand fundamentals of cell-biomaterial interactions while at the same time translational work in collaboration with clinicians is necessary to ensure appropriate design considerations for each specific local application. Ultimately, to treat patients a combination of cellular, biological, and physical signals must be presented for therapeutic impact.


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Medical Science

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  • Prügivedu

    interesting videos, thanks for sharing all this stuff

    by Prügivedu

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