Meet the Great Dane called Ranie. Dr. Tim Crowe put the Assisi loop on her neck and after just 10 minutes he began to see a difference. After 20 minutes of application he noticed definite improved coordination. She was able to rise on her own and her gait improved. Right there, within 10-20 minutes, you see her gait change. Her pain scale was thought to be about a two prior to the use of the Loop, and ten minutes afterwards it was zero.