Hematopoietic stem cells (HSCs) are the type of stem cell that give rise to all the other blood cells. They are located in the bone marrow, which is contained in the core of most bones and is the site where new blood cells come from. HSCs are able to give rise to both myeloid (monocytes and macrophages, neutrophils, basophils, eosinophils, erythrocytes, megakaryocytes/platelets, dendritic cells), and lymphoid cells (T-cells, B-cells, NK-cells). The study of HSCs over the past 50 years have provided us with a much clearer understanding of how the blood system works. More recent advances have resulted in the use of HSC transplants in the treatment of cancers and other immune system disorders
Hematopoietic stem cells - http://en.wikipedia.org/wiki/Hematopoietic_stem_cell
Dr. Connie Eaves - http://www.terryfoxlab.ca/people-detail/connie-j-eaves/
National Institute of Health "Stem Cell Reports" - http://stemcells.nih.gov/info/scireport/pages/chapter5.aspx
Blood contains many different types of cells, such as red blood cells and white blood cells, each having specific functions. Because most of these cells live for only a few days or weeks, they need to be constantly replaced.
New blood cells are produced by hematopoietic stem cells. These rare cells are found in the hollow part of bones – called the marrow. Hematopoietic stem cells are unique because they continue to make more of themselves while also producing cells destined to become specialized blood cells.
Hematopoietic stem cells can regenerate the blood-forming system if it is damaged or destroyed. Thus hematopoietic stem cell transplants can restore blood production in patients with various blood diseases or in patients who have undergone intensive cancer therapy that destroys healthy blood cells along with cancer cells.
Such transplants are the most widespread form of stem cell therapy used today and are estimated to have saved thousands of lives in the past 50 years.
Narration by: Dr. Connie Eaves
Written & Directed by: Ben Paylor & Mike Long
Produced by: Infoshots - infoshots.ca
Animation by: David Murawsky - davidmurawsky.com/
Sound by: James Wallace - http://imdb.com/name/nm0908691/
Funding by: Stem Cell Network and Canadian Stem Cell Foundation