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Prof. Olivier Bourron describes the spectacularly successful treatment, with rituximab, of a patient diagnosed with diabetes, widespread acanthosis nigricans (skin pigmentation) and polyarthralgia, with recurrent hypoglycaemia events, associated with an important weight loss. These results were published in The Lancet (see http://bit.ly/Bourron-2014-Lancet) and yielded significant press coverage (see for example Der Spiegel at spiegel.de/gesundheit/diagnose/ein-raetselhafter-patient-insulinresistenzsyndrom-verfaerbt-die-haut-a-999116.html).
More information on the research of Prof. Bourron's may be found at ican-institute.org/team/umr_s1138team-8-nutritional-and-metabolic-pathologies-obesity-diabetes/