Professor Alán Aspuru-Guzik seeks to make a difference in facing the most important challenge of the 21st century, namely the transition to a renewable energy economy. One of the key aspects that holds us back is the current slow and painful cycle of materials discovery. Alán is a pioneer in the emerging area of materials genomics: He uses a powerful combination of millions of quantum chemical calculations, state-of-the-art machine learning algorithms and big data techniques to sift through millions and millions of candidate molecules in search of the next generation of materials. He works with experimental groups around the world to collaborate in a virtuous cycle of computational design and experimental synthesis and characterization that promises to accelerate materials discovery by a factor of ten. Alán focuses on the discovery of inexpensive organic solar cells that could help provide power to the 1.4 billion people that lack access to the electrical grid. He works in the development of all-organic flow batteries for large-scale energy storage that promise to free the world from fossil fuels. He also works in the development of organic light-emitting diodes that could help provide efficient and inexpensive lighting sources with innovative form factors.