Living biofilm Communities dwelling inside of
Amyloid Plaques in Alzheimer's Brain are established
in 100 of 100 plaques examined.
This radically redefines Alzheimer's with An Infectious pathway
to the development of Alzheimer's Disease.
Amyloid is a manifestation sites of Chronic Infection
in Alzheimer's Brain tissue.
Intra-neuronal infection [ borrelia penetration
of individual neurons] sets the stage for
biochemical perturbations INSIDE of the
infected neurons, which lead to the
phosphorylation of Healthy Tau protein
to produce P-Tau proteins. Neurofibrillary
tangles form Inside of infected neurons
by a process of spontaneous self assembly.
The neurofibrillary tangles choke out the healthy
neuron microtubule system, and kill the neuron..
Borrelia infection spreads TRANS-Synaptically
along neural networks to incrementally, and to reproducibly
spread the Borrelia infection from the earliest sites
in the ento-rhinal brain to the Insular Cortex, to the
highest Brain Centers. Neurofibrillary tangles and
Amyloid plaques develop in increasing densities
in the involved anatomic regions of the Alzheimer's brain.
Microscopic examination of Autopsy confirms
a suspected diagnosis of Alzheimer's disease..
Reconciliation of the areas of anatomic
identification of neurofibrillary Tangles and
Amyloid Plaques provides the basis for the
assignment of Braak Stages of AD ( Stages I -VI)