Results from a Study of Psilocybin to Treat Obsessive-Compulsive Disorder in Humans
This study investigated the safety, tolerability, and clinical effects of psilocybin, a potent serotonin agonist, in nine patients with Obsessive Compulsive Disorder (OCD). Subjects participated in up to 4 single-dose exposures to psilocybin, separated by at least 1 week, in doses ranging from sub-hallucinogenic to frankly hallucinogenic. Sessions lasted 8-hours in a controlled clinical environment, followed by overnight hospitalization. The Yale-Brown Obsessive Compulsive Scale (YBOCS) was administered at specific intervals, and vital signs monitored. Marked decreases in OCD symptoms were observed in all subjects during 1 or more of the testing sessions (23%- 100% decrease in YBOCS score) and generally lasted at least 24 hours. In a controlled clinical environment, psilocybin was safely used in subjects with OCD and was associated with acute reductions in core OCD symptoms in several subjects.
The talk is divided into five themes: 1) A discussion of the evolution of the therapeutic paradigms used in the studies. 2) An analysis of the political and interpersonal contexts affecting the research. 3) A description of the major studies conducted at Spring Grove State Hospital and the MPRC highlighting the methodological issues. 4) A survey of the non-drug therapies that evolved from the psychedelic research. 5) The current status of research and possible future directions for psychedelic research.
This video is from Psychedelic Science in the 21st Century, a conference taking in place in San Jose, California on April 15-18, 2010. The conference was organized by the Multidisciplinary Association for Psychedelic Studies (MAPS) in collaboration with the Heffter Research Institute, the Council on Spiritual Practices, and the Beckley Foundation.
Medical doctors, nurses, psychiatrists, psychologists, social workers, and other health professionals can earn Continuing Medical Education/Continuing Education (CME/CE) credits by viewing these videos through the Spiritual Competency Resource Center (SCRC) at spiritualcompetency.com.
This video was produced by Teal Sievers of Living Dream Films (livingdreamfilms.com).
To learn more about MAPS or to support our work, visit maps.org.