This is a 3D animated video created by Sean Kirwan during a Knowledge Exchange Dissemination Scheme (KEDS) with University College Dublin and ICON Firecrest, funded by the Health Research Board. Lead Pharmacologist was Sean Kirwan and 3D Graphic Designer was Tomás O'Sullivan. Support Pharmacologists were Dr Paul Halley and Dr James Corcoran. Dr Breandán Kennedy (UCD) was project supervisor.