In São Paulo, the rapid pace of change and critical crises across many sectors suggest opportunities for human-centered advancement that design can help inform. In October 2016, IIT Institute of Design embarked on its second year of the Strategy World Tour with a three day tour of São Paulo. A small group of designers, executives, researchers and students participated in the immersive experience. We visited leaders of the emerging fintech industry like Nubank and Jeitto—leveraging new digital technology to provide financial services previously unavailable in the region—as well as leadership pushing the envelope on creative banking solutions. We met influential venture capitalists who support startups and workshop in the maker space WE FAB. We visited Fluxo, a networked journalism collective created by Bruno Torturra, responsible for Mídia Ninja, a journalism phenomenon that emerged from the protests in Brazil. We explored emerging examples of innovation solutions in education and those stemming from the global maker movement.