There has been increased interest in the clinical laboratory to develop comprehensive LC-MS/MS assays for urine drug testing, with fifty or more drugs and metabolites from multiple drug classes in a single method.
These panels can increase throughput and improve laboratory efficiency, but create many challenges. Considerations for developing robust sample preparation methods for acidic, basic and neutral drugs for pain management and compliance testing in hydrolyzed urine specimens will be discussed. Method development strategies depending upon the drug analytes of interest will be presented.
Recorded on March 9 2017.
Presented by Ph. D. Stephanie J. Marin, Senior Applications Chemist at Biotage
