September 5th, 2017, Colloquium
Michael Vella discusses theoretical analysis of gene drive countermeasures that could be used to reverse a CRISPR-based homing drive. Countermeasures include synthetic resistance alleles, reversal drives, and immunizing reversal drives. Unexpected dynamics arise in some cases, and each countermeasure has advantages and disadvantages that would need to be considered before use.
Sumit Dhole then delves into a comparative analysis of three gene drives that have been proposed for localized population alteration – the one- and two-locus under-dominance drives, and the recently proposed daisy-chain drive.
Evaluating Strategies For Reversing CRISPR-Cas9 Gene Drives
Invasion and migration of self-limiting gene drives: a comparative analysis