Genetically modified mice are used extensively in research as models of human disease. They have been used to study and model obesity, heart disease, diabetes, arthritis, substance abuse, anxiety, aging and Parkinson disease. A “humanized mouse” is a mouse carrying functioning human genes, cells, tissues, and/or organs. Humanized mice are commonly used as small animal models in biological and medical research for human therapeutics. Immunodeficient mice are often used as recipients for human cells or tissues, because they can relatively easily accept heterologous cells due to lack of host immunity. Traditionally, the nude mouse and the severe combined immunodeficiency (SCID) mouse have been used for this purpose, but recently the NOG mouse and the NSG mouse have been shown to engraft human cells and tissues more efficiently than other models

Loading more stuff…

Hmm…it looks like things are taking a while to load. Try again?

Loading videos…