Rapid Precision Medicine is being advanced through research at the Rady Children’s Institute for Genomic Medicine. Using Rapid Whole Genome Sequencing (rWGS), the Institute is enabling the prevention, diagnosis and treatment of rare genetic diseases. The work is also providing evidence for the economic utility of rWGS in critically-ill infants with undiagnosed diseases. Dr. Stephen Kingsmore will discuss the case of a newborn who was the youngest patient ever to be diagnosed with Otahara Syndrome caused by a novel KCNQ2 mutation as a result of rWGS. The diagnosis was obtained in just four days, allowing doctors to immediately and successfully adjust treatment. Thus far, the infant is stable, at home and has avoided further seizures and neurological damage. In other cases, this syndrome almost inevitably leads to severe neurological damage with a 50 percent mortality rate by age two.