The main effect of inhaling xylene vapour is depression of the central nervous system (CNS), with symptoms such as headache, dizziness, nausea and vomiting. Volunteers have tolerated 100 ppm, but higher concentrations become objectionable. Irritation of the nose and throat can occur at approximately 200 ppm after 3 to 5 minutes. Exposures estimated at 700 ppm have caused nausea and vomiting. Extremely high concentrations (approximately 10000 ppm) could cause incoordination, loss of consciousness, respiratory failure and death. In some cases, a potentially fatal accumulation of fluid in the lungs (pulmonary edema) may result.