Vein preservation is a critical topic that few clinicians think about let alone practice. Venous injury and thrombosis lead to vein loss and significantly contributes to venous depletion and difficult venous access. For patients with renal insufficiency, vein loss limits their ability to obtain functional fistula for life saving dialysis. We must understand the cause of venous depletion and create access strategies to preserve veins. This presentation will review what is currently known regarding vein loss and what can be done to help preserve veins