LZTR1 @Superti-Furga laboratory @CeMM Bigenzahn et al Science 2018
Who regulates the key regulator? The Superti-Furga laboratory at CeMM reports online in the journal Science about a newly discovered mechanism by which RAS proteins, central to cancer signaling, are regulated in their activity and localization. Link to the study: science.sciencemag.org/content/early/2018/11/14/science.aap8210.
The research team at CeMM (first author: Johannes Bigenzahn, last author: Giulio Superti-Furga) found that the protein called LZTR1, in concert with its copartner cullin 3, regulates RAS by attaching to it a small molecular tag, called ubiquitin. The modified RAS proteins demonstrate altered localization within the cell and reduced abundance. Mutational defects or inactivation of LZTR1 lead to an increase of RAS dependent pathways causing dysregulation of growth and differentiation. LZTR1 can therefore be considered a breaker of RAS action.
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