Coherent Diffraction Microscopy and Its Applications in Nanoscience and Biology
Jianwei (John) Miao
Department of Physics & Astronomy and California NanoSystems Institute, University of California, Los Angeles
For centuries, lens-based microscopy, such as light, phase-contrast, fluorescence, confocal and electron microscopy, has played an indispensable role in the evolution of modern sciences and technologies. In 1999, a novel form of microscopy, i.e. coherent diffraction microscopy (also termed coherent diffraction imaging or lensless imaging) was developed and transformed our traditional view of microscopy, in which the diffraction pattern of a non-crystalline object is measured and then directly phased to obtain an image by computational algorithms. The well-known phase problem is solved by the oversampling method whose principle can be traced back to the Shannon sampling theorem. In this talk, I will briefly discuss the principle of coherent diffraction microscopy and illustrate its broad applications in nanoscience and biology by using modern coherent X-ray sources.