Autoimmune diseases, which are often chronic, debilitating, and life-threatening, affect millions of people in the United States alone. Robert Kimberly, MD, will explain the role that two types of autoimmune molecules, IgG and IgA autoantibodies, play in these diseases. He will also describe the importance of biologically significant, genetically determined differences in shaping the response to these antibodies. In the autoimmune disorder Wegener's granulomatosis, for example, the combination of IgA autoantibody and specific receptor variants is strongly associated with kidney damage. This relationship sets the paradigm for the coming together of the sciences of genomics and proteomics for predictive personalized medicine.