Bioinspired Molecules: From Protein Chemistry to Drug Design
Department of Inorganic & Physical Chemistry, Indian Institute of Science, Bangalore
Bioinspired chemistry is one of the most intellectually attractive and experimentally demanding frontiers in modern chemical science. For many years, the extraordinary chemistry of biological systems inspired chemists to design and synthesize molecules that mimic the natural systems. These bioinspired molecules are helpful not only for understanding the complex biochemical reactions, but also for the design and synthesis of drugs for clinical applications. In this lecture, the role of metal ions in biology, particularly in metalloproteins, will be discussed. The chemistry at the metal centers of metalloproteins will be discussed with the help of synthetic model compounds. Particularly, the lecture will focus on how model complexes can be used to understand more about metals in metalloenzymes that catalyze extremely complex reactions. Finally, the applications of metalloproteins in drug design will be briefly discussed.
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