What you will learn from this webinar:
-How our advanced sequencing platform uncovers the direct transcriptional targets of a compound.
-How our machine learning suite quantifies the activity of more than 800 transcription factors simultaneously.
-How integration of these approaches equips our sponsors for success from early development through the clinic.
Understanding a drug’s mechanism of action is the key to unlocking its full therapeutic potential. Using advanced sequencing methods, Clarion detects a novel class of RNAs: enhancer RNAs. Measurements of these active, non-coding genomic elements are fed into Clarion’s machine learning framework, which simultaneously detects a compound’s impact on gene targets, signaling pathways, transcription factor activity, and the epigenetic landscape. This comprehensive snapshot of what is happening inside the cell following treatment enables the disentangling of a drug's primary and downstream effects, providing a thorough, mechanistic understanding of the compound. Arpeggio serves as a trusted scientific advisor to provide the data and insights needed to answer complex scientific questions – everything from study design and implementation to data reports and interpretation. Clarion is the only platform that offers information about gene expression, epigenetic modulation, transcription factor activity, and cellular pathways, all in a single experiment.