Individuals and families affected by disability and chronic illness face moral predicaments and ethical dilemmas. They must decide about participating in drug trials and research studies, supporting "curative" organizations, medicating behaviors, activating a DNR, pursuing guardianship, praying for healing, and more. As Christians, how do we resist cultural collapse when it comes to these kinds of issues? How can friends, family, caregivers, and churches provide support and foster a decision-maker’s biblical worldview? We will explore common scenarios using a biblical framework for decision-making that is God-honoring, life-edifying, and peace-giving.