Nanoshells for Photothermal Cancer Therapy
Jennifer West, Rice University
Metal nanoshells are a new class of nanoparticles with highly tunable optical properties. Metal nanoshells consist of a dielectric core nanoparticle such as silica surrounded by an ultrathin metal shell, usually composed of gold for biomedical applications. Depending on the size and composition of each layer of the nanoshell, particles can be designed to either absorb or scatter light over much of the visible and infrared regions of the electromagnetic spectrum, including the near infrared region where penetration of light through tissue is maximal. These particles are also easily conjugated to antibodies and other biomolecules. One can envision a myriad of potential applications of such tunable particles. Several potential biomedical applications are under development, including immunoassays, modulated drug delivery, photothermal cancer therapy, and imaging contrast agents. For example, in photothermal cancer therapy, nanoshells can be injected intravenously, accumulate at tumor sites due to the EPR effect and/or molecular targeting, then generate heat upon illumination with near infrared light, leading to destruction of the tumor. This has shown very promising results in a mouse colon carcinoma model, with 100% survival of nanoshell treated mice at 1 year. Furthermore, integrated imaging and therapy applications have been accomplished with these materials.
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