Satoshi Murata, Tokyo Institute of Technology
DNA nanotechnology is one of the emerging nanotechnologies utilizes physical and biological properties of DNA molecules. As building material of nanostructure, DNA molecules have advantages such as chemical stability, easiness of mass production and specific hybridization between complementary base sequences. The last property is especially important for programmable assembly of nanostructure. Using the complementary strands of DNA as molecular connectors, various systems such as molecular computer, intelligent medicine and molecular memory can be realized.
Various kinds of DNA motifs have been proposed as building blocks of nanostructure. Among them, one of the most popular and powerful motifs is called a DNA tile. The DNA tile is a rigid supermolecule composed of two interwoven DNA double helices. It has four “sticky ends” at the ends of the double helices. It is proven that DNA tiles have capability of computation. Recently, ability of DNA tiles to self-assemble two-dimensional nanostructure has been experimentally examined. It is possible to make programmed periodic or aperiodic patterns on a lattice made of DNA tiles.
2. Error Suppression of DNA tile self-assembly
Suppression of assembly errors is essentially important to reap the benefits of the nanostructure. We have to cope with several kinds of errors accompanied by self-assembly process. These errors are mainly caused by mismatch of the sticky ends of non-complementary strands (Fig.1).