Correlative cryo-SIM/FIB-SEM reveals a web-like adhesion pattern between adjacent cerebellar granule neurons.
Part 1: Cryo-SIM and FIB-SEM volume renderings of a field of CGNs expressing adhesion proteins JAM-C (green) and drebrin (magenta).
Part 2: Correlation between electron density at the plasma membrane, JAM-C cryo-SIM signal, and plasma membrane curvature at the interface between two CGNs.
For more information: janelia.org/news/new-technique-reveals-cell-structure-by-combining-light-microscopy-and-electron-microscopy
Credit: D. Hoffman et al./Science 2020