In collaboration with three tribal communities in the Northwest, the Culturally Responsive Indigenous Science (CRIS) project catalyzes new approaches to Indigenous science teaching and learning through land-based science curriculum and hands-on enrichment programs that weave Indigenous knowledges and languages with western science and digital tools to increase Native American students’ learning, engagement and achievement across the sciences. Core to the project’s innovation, the CRIS project team includes tribal language/culture teachers, school science, mathematics, special education teachers, university faculty, and graduate students. Through a community-based approach to curriculum design, the project team collaborates to develop land-based science curriculum that weaves together traditional ecological knowledge, language, technology and western science in ways that address national science standards while honoring tribal culture, language, and sovereignty. To accomplish this, the CRIS team gathers quarterly in each tribal homeland and at Washington State University to develop curriculum modules, engage in teacher professional development, and provide enrichment programming for Native American youth. All project activities are designed for students and teachers to critically problem-solve local issues related to the environment and sustainability from the perspective of traditional knowledge, stories, and language. The modules include innovative lessons with H5P interactive content, digitized and archived cultural materials from the Plateau Peoples’ Web Portal, and media resources. Teachers and students utilize the CRIS project website and iPad application to access the modules, engage in interactive lessons, gather content, and create video and project-based assessments. This project builds bridges between schools, tribal departments, and communities and develops a regional network of support across tribal nations.