.This talk, from the Lean Software and Systems Conference 2012 (LSSC12), discusses how to achieve multiple team collaboration in large scale software development. Self-organization is a key concept for all Lean-Agile methods. However, as projects expand across the enterprise and, more specifically, cut across multiple teams, teams clearly can’t just organize in any way they want to. A blend of top-down direction with bottom-up self organization is needed. Lean provides the insights necessary for teams to self-organize within the context of the value stream within which the teams work. A top-down perspective, created by driving from business value, can provide insights on how teams must organize and work together.