The promise of genomics gives humankind the hope of unprecedented future biomedical innovations. But the pace of biomedical innovation has slowed down dramatically, even as our understanding of fundamental disease biology and ability to capture data at the molecular/genomic level has increased exponentially. There has been an increasing call to action to move to novel partnerships and open source models of innovation, where multiple parties in both the private and public sectors collaborate, early stage discoveries benefit from shared knowledge and datasets, and innovations can incubate in a pre-competitive space. The idea of sharing risks and rewards to better the welfare of humankind is certainly inviting, but is it really possible to navigate across various stakeholder interests and collaborate effectively? And when the next “big idea” comes are the benefits shared? Come and hear the experiences of Eric Schadt, a renowned pioneer in driving new models of innovation, co-founder of Sage Bionetworks, Director of the Institute for Genomics and Multiscale Biology, and Chair of the Dept. of Genetics and Genomics Sciences at Mt. Sinai Medical School, followed by a provocative conversation between Dr. Schadt and Dr. Brian Athey, moderated by Connie Chang, Director of U-M Medical School Business Development.