The HCV is usually transmitted through blood-to-blood contact. The virus replicates in the hepatocytes of the liver and circulates throughout the body. Entry into hepatocytes occurs through the interaction of the viral envelope with receptors on the surface of the host cell. The virus undergoes a fusion and uncoating step, releasing positive-strand viral RNA. HCV utilizes many of the host cell’s proteins and molecules in order to replicate. The first step is the translation of the viral RNA genome into a polyprotein.

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