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In 2003, biologists created the first ever human genome sequence. The 3 billion DNA letter sequence, called the reference genome, was mostly made up of DNA donated from people in the city of Buffalo, New York. So far, when clinicians and researchers study an individual’s genome, they compare it to the reference genome to identify differences. But can you compare all of humanity to one genome? No, because one reference genome does not convey the genomic diversity of the human species. We need many reference genomes--a pangenome. This monumental undertaking is already taking place and is poised to redefine the future of genomic research and human health.
A co-production of Massive Science (massivesci.com/) and NIH/NHGRI (genome.gov/).
Presented by the National Human Genome Research Institute genome.gov/
Direction and Animation by Rosanna Wan rosanna-wan.com/
Narration by Dr. Shawntel Okonkwo shawntelokonkwo.com/
Sound + Music by Skillbard skillbard.com/
Script by Harriet Bailey and Prabarna Ganguly
Producer Harriet Bailey harriet-bailey.com/
Senior Producer Nadja Oertelt nadjaoertelt.com/
Executive Producer Prabarna Ganguly prabarnaganguly.com/
Produced for and supported by the National Human Genome Research Institute
Winner of the 2020 DCSWA Newsbrief Award (multimedia category) dcswa.org/newsbrief-award/