Microorganism, such as bacteria like E. coli, have several applications in the biopharma, food, and agriculture industry. Process monitoring and control are of the highest importance in the manufacturing of such microorganisms to allow good product quality when monitoring the growth kinetics of the cells. This limited linear range of traditional UV brings a challenge when adapting optical density measurements as an in-line or at-line monitoring tool for cell growth in bioreactors. The variable path-length technology from C Technologies, a Repligen company, overcomes this challenge by increasing the linear range between the absorbance and cell concentration.
