There are three major causes of Magnesium deficiencies: 1) Stress 2) Diuretics 3)Diet (Refined Carbohydrates. Magneisum can not be made by the body so you need to source it from food and minerals. We replete our Magnesium from eating raw vegetables and nuts. Cooked foods are depleted of Magnesium minerals. There are three way of repleting our Magnesium level 1) Through Intravenous 2) Through Oral Supplement 4) Through Transdermal or skin. There are no reported overdose from Transdermal Therapy versus oral. The side effect of oral overdose gives your diarrhea. Check with your health practitioners if you have low blood pressure or kidney problems before repleting your Magnesium level through oral and intravenous method.