Implantable Microsystems for Quantitative Measurement of Biomolecules for the Management of Hemorrhagic Shock
Continued high morbidity and complications due to trauma related hemorrhage underscores the fact that our understanding of the detailed molecular events of trauma are inadequate to bring life-saving changes to practice. The current state of efficacy of trauma diagnostics concerning hemorrhage and hemorrhagic shock was considered with respect to vital signs and metabolic biomarkers. Tachycardia and hypotension are markers of hemorrhagic shock in decompensated trauma patients. Base deficit has been predicative of injury severity at hospital admission. Tissue oxygen saturation has been predicative of onset of multiple organ dysfunction syndrome. Blood potassium levels increase with onset of hemorrhagic shock. Lactate is a surrogate for tissue hypoxia and its clearance predicts mortality. Insulin resistance and attendant triage glucose measurements have been shown to be specific in predicting major injuries. No vital sign has yet to be proven effective as an independent predictor of trauma severity. Implantable point-of-care (POC) analytical microsystems are being developed for use by first responders to allow for rapid, continual monitoring of glucose and lactate via dual responsive amperometric enzyme biosensors, tissue acidosis via impedimetry and VO2 via voltammetry. Multi-analyte monitoring biosensors have the potential to explore areas still unexplored in the realm of trauma physiology.
Anthony Guiseppi-Elie is Professor of Chemical and Biomolecular Engineering, Bioengineering, and Electrical and Computer Engineering. He is also Director of the Center for Bioelectronics, Biosensors and Biochips at Clemson University. He is Founder and Scientific Director of ABTECH Scientific, Inc., a near-patient biomedical diagnostics company. He holds the Sc.D. in materials science and engineering from MIT, the M.Sc. in chemical engineering from the University of Manchester Institute of Science and Technology (UMIST) and the B.Sc. (First Class Honors) with majors in Analytical and Applied Chemistry from the University of the West Indies (UWI). He has spent 15 years in industrial research and product development before becoming a full professor of Chemical and Life Science Engineering and of Emergency Medicine at VCU-MCV in 1998. His research interests are in engineered bioanalytical microsystems in the service of human health and medicine. He has published over 120 archival papers (2369 citations, h-factor = 26), 31 book or proceedings chapters, holds 8 patents, has given > 200 invited lectures/colloquia, and has co-organized and lead 30 national and international scientific workshops, symposia and conferences. He is an Associate Editor of Biomedical Microdevices and a member of the editorial boards of The Journal of Bioactive and Compatible Polymers, NanoBiotechnology, Applied Biochemistry and Biotechnology. Dr. Guiseppi is a Fellow of AIMBE, senior member of IEEE, a lifetime Member of AIChE and holds memberships in RSC, AAAS, ACS, MRS and BMES. At Clemson University Prof. Guiseppi teaches engineering materials, biological transport phenomena, biomolecular engineering, biosensors and bioelectronics, and nanobiotechnology.