Nuclear Reprogramming - Sheng Ding, The Scripps Research Institute

A chemical approach to pluripotency and reprogramming

Sheng Ding, The Scripps Research Institute

Presentation abstract: Recent advances in stem cell biology may make possible new approaches for the treatment of a number of diseases. A better understanding of molecular mechanisms that control stem cell fate as well as an improved ability to manipulate them are required. Toward these goals, we have developed and implemented high throughput cell-based phenotypic screens of arrayed chemical and gene libraries to identify and further characterize small molecules and genes that can control stem cell fate in various systems. This talk will provide latest examples of discovery efforts in my lab that have advanced our ability and understanding toward controlling stem cell fate, including self-renewal, survival, differentiation and reprogramming of pluripotent stem cells.