IRMACS: The Interdisciplinary Colloquium "An Interdisciplinary Approach to Bioinformatics: The PSORTb Software for Protein Localization Prediction"
Jennifer L. Gardy
Department of Molecular Biology and Biochemistry
Date: Nov 10, 2005
Time: 11:30 -
Our group has led the development of PSORTb - a computational method that predicts where in a bacterial cell a newly synthesized protein will be directed to. This information has a number of applications, from helping to annotate genomes to identifying which proteins in a disease-causing bacterium represent potential drug or vaccine targets. As part of the development process, we worked closely with three researchers in SFU's Computing Science department on both the development of predictive methods based on data mining and support vector machine, as well as appropriate statistical methods for generating a final prediction. Now that the initial development of PSORTb is complete, we have been focusing on analysis of the data from a genomic perspective. Through collaboration with statistics researchers, we are uncovering trends in protein localization with interesting biological implications. For more information, visit psort.org/psortb.