University of Miami, Miami, FL
The nerve cell type retinal ganglion cells (RGCs) integrate visual and non-visual information from the eyes and send these signals into the brain through their long “arms,” or axons. This three-dimensional fluorescence imaging video shows RGC axons connecting one eye to other key areas of the brain in a mouse. Glaucoma causes the degeneration of the RGC axons, RGC death, and irreversible vision loss. Therefore, intensive research has focused on identifying strategies to promote RGC survival, axon regeneration, and reestablish connections between RGCs and other brain cells. This work is supported by the NIH National Eye Institute and the US Army.