Graham Johnson (grahamjlab.org/) gives a fascinating talk about his career trajectory as a biomedical illustrator and introduces some molecular graphics tools that he is co-developing. He also discusses the challenges of visualizing objects in the "mesocale", the scale of macromolecular structures in cells, which is difficult to observe directly. Graham shows how the tools he has co-developed, uPy and autoFill, can automatically build models based on data which are richly detailed, informative, and consistent with current knowledge. This talk was presented at the VIVID Sydney festival (vividsydney.com) on 30 May 2013 as part of the VIVID Ideas "Connect with Science" event. This video was filmed and distributed with permission under a Creative Commons license.