Alex has a sweet smile that melts the heart of everyone he meets. For 3 years, Alex has braved countless tests and visits to see some of the best pediatric neurologists in the USA. However, this disease that slowly robs Alex of his abilities is yet to be understood or diagnosed. This is video and photos documenting the progression of the disease over a period of 5 years. Though Alex is now both physically and verbally challenged, he still has his playful sense of humor and remains remarkably cognizant. We continue to relentlessly search for diagnosis and treatments for Alex.